Any cutest guys in the world list will never be complete without this American actor. That piercing stare and gorgeous pout say it all. He became popular for his role in the TV series 21 Jump Street in the 80’s. What’s amazing about Depp is that he has a timeless beauty that makes the hearts of youngsters and adults skip a beat. Even now that he’s over 50, his charm never fades. His good heart is a bonus, making him beautiful inside and out.